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The Role of Probiotics in the Prevention of Colorectal Cancer: Literature Review

July-September 2016, Volume 03, Number 3
Iván Armando Osuna-Padilla, María Guadalupe Serna-Thomé, Horacio Noé López-Basave, Martín Granados-García, Ángel Herrera-Gómez and Alejandro Eduardo Padilla-Rosciano
Instituto Nacional de Cancerología, Mexico City, Mexico

Colorectal cancer is one of the most common types of cancer worldwide, being the fifth most common cancer in Mexico. Probiotic bacteria are living microorganisms that, when administered in reasonable quantities, provide the host with health benefits. Several studies have shown the effectiveness of probiotics in the prevention of some diseases such as cancer, infections, allergies, irritable bowel syndrome, and other autoimmune diseases. Regarding the prevention of colorectal cancer, several action mechanisms have been proposed, with a highlight on the sequestration mechanism of mutagens by intestinal bacteria, the bacteria growth suppression that converts pro-carcinogens into carcinogens, the reduction of enzymes β-glucuronidase and β-glucosidase, bile acid de-conjugation, as well as the potentiation of the host immune system.

Key words:
Colon cancer. Dysbiosis. Lifestyle. Microbiota. Probiotics. Rectal cancer.
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