The maxillary bones are the most important bones of the facial skeleton. They provide support to the base of the skull and are essential to the voice box, causing maxillary defects that occur following tumor resection or trauma to result in the loss of some functions such as phonation, deglutition, mastication, respiration, and aesthetics as well as loss of self-esteem. The aim of this paper is to show how prosthetic rehabilitation has multiple impacts on the phonatory and respiratory systems.