Triple-negative breast cancer is the most aggressive subtype of breast tumors. After a better molecular understanding of breast cancer, the treatment of triple-negative tumors is challenging because there is no known potential therapeutic target. Recently, interesting data about the use of platinum has been published and has generated excitement, especially in patients harboring mutations in BRCA gene. In this paper, the use of platinum agents will be reviewed as a new therapeutic option for mutated BRCA and triple-negative breast cancer.