In the last two decades the US Food and Drug Administration has granted approval for multiple molecules for use in the treatment of cancer. These targeted therapies, aimed at inhibiting specific molecules, cause numerous adverse effects at the skin, for example, acneform dermatitis, mucosal, hair and nail alterations, and depigmentation of skin and hair, which have been seldom described in the literature. In this article we will focus on the side effects of tyrosine kinase inhibitors in particular and try to show how these drugs affect melanogenesis in hair follicles, triggering changes in skin and hair pigmentation.